Clinical Trials

  • Principal Investigator:

    Sharon L Wardlaw, MD
    The goal of this project is to understand why bariatric surgery is such an effective treatment for obesity with a focus on brain mechanisms. Cerebrospinal fluid neuropeptides, hormones, and protein levels will be measured in subjects before and after bariatric surgery as compared with subjects before and after diet-induced weight loss. Participants in the diet arm will follow a low-calorie liquid diet (Optifast) for approximately 12 weeks. They will have two lumbar punctures (spinal taps) and liquid test meal challenges, as well as weekly nutritionist counseling. These participants will...
  • Principal Investigator:

    Wendy Kay Chung, MD
    Study examining the genetic causes of birth defects.
  • Principal Investigator:

    Wendy Kay Chung, MD
    Study examining the genetic causes of birth defects.
  • Principal Investigator:

    Wendy Kay Chung, MD
    Each year more than 1,000 babies in the United States are born with a Congential Diaphragmatic Hernia (CDH). For the majority of these babies, the cause of the CDH is unknown. DHREAMS (Diaphragmatic Hernia Research & Exploration; Advancing Molecular Science) study was created to improve the understanding of the molecular genetic basis of CDH. This National Institute of Health (NIH)-funded research team is composed of health care providers and researchers across the country, coordinated at Columbia University Medical Center. Multiple medical centers are enrolling individuals and families...
  • Principal Investigator:

    Judy Korner, MD
    The purpose of these studies is to gain an understanding of the mechanisms that promote weight loss and improved glucose control. The ultimate goal is to identify therapeutic pathways for obesity and diabetes as a way to optimize surgical procedures and discover novel non-surgical targets for safe and effective drug therapy.
  • Principal Investigator:

    Adi Cohen, MD
    We are studying the causes of and potential treatments for pregnancy & lactation associatedosteoporosis (PLO). We know little about the clinical features, causes, and prognosis of PLO. Our goal is to define the clinical characteristics of PLO and better understand similarities/differences among the women. We are looking for women with fractures during/soon after pregnancy or while breastfeeding.
  • Principal Investigator:

    Blandine Laferrere, MD
    This is a randomized trial that will examine the effect of self-monitoring food intake via a smart phone application, and of a novel lifestyle intervention called time restricted eating, on improvement of metabolic health in persons with overweight or obesity. The intervention lasts 12 months and will be administered via a smartphone app. Participants will use the app to take pictures of all food and drinks, everyday for 3 months, then 10 days a month for the following 9 months. Participation requires one screening visit (~1hr), and eight outpatient visits (~1-5hr) including an IV catheter in...
  • Principal Investigator:

    Dympna Gallagher, EdD
    The aim of this study is to estimate the surface area of the body of children using digital photography. During a 10 second scan, four cameras mounted on 4 poles photograph the surface of the body from head to toes. The system is used by the fashion industry for custom tailoring to design well fitted apparel. We seek to compare body surface area estimates using this system with the standard height and weight based equations used in clinical medicine. The study is recruiting children aged 3-17 years. The system uses safe laser light cameras and takes about 10 seconds for one scan. Participant...