Clinical Trials

  • Principal Investigator

    Wendy K. Chung, MD, PhD
    The purpose of this research is to determine whether a new investigational drug called TAK-935 is safe and whether it may help treat epilepsy in children with 15q duplication syndrome or CDKL5 deficiency disorder.
  • Principal Investigator

    Wendy K. Chung, MD, PhD
    Several children are born with birth defects every day. Through extensive genetic research, we have learned over the years that there are genetic factors that can contribute to the occurrence of some of these defects, especially in children with more than one congenital defect. However, the underlying genetic causes of many birth defects still remain unknown. The goal of this study is to use a sophisticated technology called whole exome/genome sequencing to identify underlying genetic causes of surgical birth defects.
  • Principal Investigator

    Wendy K. Chung, MD, PhD
    CARE is a new research initiative that aims to investigate the underlying genetic causes of various birth defects. By identifying the cause of these defects, we hope to be able to better understand their natural history which may ultimately lead to better treatment and management. Knowing the genetic causes of birth defects also allows us to assess the hereditary risk of the defect in a family. The study is free and involves submission of a blood or saliva sample from a child with a birth defect and both parents.
  • Principal Investigator

    Wendy K. Chung, MD, PhD
    Each year more than 1,000 babies in the United States are born with a Congential Diaphragmatic Hernia (CDH). For the majority of these babies, the cause of the CDH is unknown. DHREAMS (Diaphragmatic Hernia Research & Exploration; Advancing Molecular Science) study was created to improve the understanding of the molecular genetic basis of CDH. This National Institute of Health (NIH)-funded research team is composed of health care providers and researchers across the country, coordinated at Columbia University Medical Center.
  • Principal Investigator

    Sharon E. Oberfield, MD
    We are recruiting boys between 3-9 years old and girls between 3-8 years old to participate in a research study. Children who would like to participate must be healthy and not showing signs of puberty. The goal of the study is to understand the relationship between early body development, metabolism (sugars and fats processing), and the saliva microbiome (bacteria that normally live inside the body). The study is performed in the morning after an overnight fast and may be completed in less than 2 hours.
  • Principal Investigator

    Sharon E. Oberfield, MD
    We are recruiting boys between 3-9 years old and girls between 3-8 years old to participate in a research study. Children who would like to participate must be healthy and not showing signs of puberty. The goal of the study is to understand the relationship between early body development, metabolism (sugars and fats processing), and the saliva microbiome (bacteria that normally live inside the body). The study is performed in the morning after an overnight fast and may be completed in less than 2 hours.
  • Principal Investigator

    Wendy K. Chung, MD, PhD
    This study is designed to determine the role of specific genes in obesity and/or type 2 diabetes mellitus. Patients who are severely obese, and/or with an onset of type 2 diabetes at less than 25 years of age. Ideally, we would like to have families involved in this study. The ideal family is one in which NOT everyone in the family is obese or diabetic. Families in which one or neither parent is obese/diabetic, and some but not all children are obese/diabetic, are ideal.
  • Principal Investigator

    Wendy K. Chung, MD, PhD
    The goal of this study is to better understand the genetic causes of weight gain and identify individuals who may benefit from a new treatment to help them maintain a healthy weight. Your participation will help us understand how why some people gain more weight and how individuals can stay at a healthy weight. We will ask you questions about your weight and your height to determine if you are eligible. If you are eligible, we will invite you to participate.
  • Principal Investigator

    Judith Korner, MD, PhD
    The purpose of these studies is to gain an understanding of the mechanisms that promote weight loss and improved glucose control. The ultimate goal is to identify therapeutic pathways for obesity and diabetes as a way to optimize surgical procedures and discover novel non-surgical targets for safe and effective drug therapy.
  • Principal Investigator

    Adi Cohen, MD
    Pregnancy and lactation associated osteoporosis (PLO) is a severe, early presentation of osteoporosis in which young women present during late pregnancy or lactation with low trauma or spontaneous fractures, most commonly vertebral fractures. The goal of this study is to define the clinical characteristics of PLO, and to better understand both similarities and differences among women with PLO. Participants are invited to participate in studies of bone structure, bone metabolism, hormones and genetics. Studies take place at Columbia University Medical Center.