Clinical Trials

  • Principal Investigator:

    Sharon L Wardlaw, MD
    The goal of this project is to understand why bariatric surgery is such an effective treatment for obesity with a focus on brain mechanisms. Cerebrospinal fluid neuropeptides, hormones and protein levels will be measured in subjects before and after bariatric surgery as compared with subjects before and after diet-induced weight loss. Participants in the diet arm will follow a low-calorie liquid diet (Optifast) for approximately 12 weeks. They will have two lumbar punctures (spinal taps) and liquid test meal challenges, as well as weekly nutritionist counseling. These participants will...
  • Principal Investigator:

    Wendy Kay Chung, MD
    Several children are born with birth defects every day. Through extensive genetic research, we have learned over the years that there are genetic factors that can contribute to the occurrence of some of these defects, especially in children with more than one congenital defect. However, the underlying genetic causes of many birth defects still remain unknown. The goal of this study is to use a sophisticated technology called whole exome/genome sequencing to identify underlying genetic causes of surgical birth defects. The identification of such genes, and examination of their structure and...
  • Principal Investigator:

    Wendy Kay Chung, MD
    CARE is a new research initiative that aims to investigate the underlying genetic causes of various birth defects. By identifying the cause of these defects, we hope to be able to better understand their natural history which may ultimately lead to better treatment and management. Knowing the genetic causes of birth defects also allows us to assess the hereditary risk of the defect in a family. The study is free and involves submission of a blood or saliva sample from a child with a birth defect and both parents. If you have a child with a birth defect and would be interested in enrolling,...
  • Principal Investigator:

    Wendy Kay Chung, MD
    Each year more than 1,000 babies in the United States are born with a Congential Diaphragmatic Hernia (CDH). For the majority of these babies, the cause of the CDH is unknown. DHREAMS (Diaphragmatic Hernia Research & Exploration; Advancing Molecular Science) study was created to improve the understanding of the molecular genetic basis of CDH. This National Institute of Health (NIH)-funded research team is composed of health care providers and researchers across the country, coordinated at Columbia University Medical Center. Multiple medical centers are enrolling individuals and families...
  • Principal Investigator:

    Judy Korner, MD
    The purpose of these studies is to gain an understanding of the mechanisms that promote weight loss and improved glucose control. The ultimate goal is to identify therapeutic pathways for obesity and diabetes as a way to optimize surgical procedures and discover novel non-surgical targets for safe and effective drug therapy.
  • Principal Investigator:

    Dympna Gallagher, EdD
    The aim of this study is to estimate the surface area of the body of children using digital photography. During a 10 second scan, four cameras mounted on 4 poles photograph the surface of the body from head to toes. The system is used by the fashion industry for custom tailoring to design well fitted apparel. We seek to compare body surface area estimates using this system with the standard height and weight based equations used in clinical medicine. The study is recruiting children aged 3-17 years. The system uses safe laser light cameras and takes about 10 seconds for one scan. Participant...